Brequinar and dipyridamole in combination exhibits synergistic antiviral activity against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19Research article Published on 2022-10-012022-10-05 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] acute respiratory syndrome Antiviral antiviral activity Antiviral treatment B.1.351 B.1.617.2 Beta Brequinar cellular Combination coronavirus coronavirus disease COVID-19 de novo deaths Delta DHODH Dihydroorotate dehydrogenase (DHODH) Dipyridamole drug treatments effective enzyme evade Evolution of SARS-CoV-2 exhibit global pandemic Host host cell in vitro Infection infections inhibitor maintain medical need monoclonal antibody nucleotide pathway rationale Replication required resulting RNA virus SARS-CoV-2 SARS-COV-2 infection selective shown Support synergistic therapy treat Treatment Vaccine variants viral replication [DOI] 10.1016/j.antiviral.2022.105403 [Article Type] Research article
Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular DiseaseArticle Published on 2022-09-012022-11-16 Journal: Cells [Category] 유전자 메커니즘, [키워드] alleviate antioxidants Arrhythmias Atherosclerosis Cardiomyopathy cardiovascular cardiovascular disease Cell cell death characterized conditions Critical CVD cytoplasmic Defense demonstrated detoxify DHODH enzyme activity Evidence expected Fenton reaction Ferroptosis genetic manipulation heart failure implication induce inhibitors Injury involved iron lipid peroxidation LOX membrane mitochondria. mitochondrial mitochondrial membrane molecular mechanism Pathogenesis Pathways peroxidase Protein regulated Relevance ROS therapeutic option [DOI] 10.3390/cells11172726 PMC 바로가기
A Bioluminescent 3CL Pro Activity Assay to Monitor SARS-CoV-2 Replication and Identify InhibitorsArticle Published on 2021-09-122022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] 3CL activity Anti-SARS-CoV-2 Activity Antiviral BAY2402234 Cell cell line cellular chemical screening cleavage site Compound Consensus coronavirus Coronaviruses Critical develop DHODH effective expressing expression firefly luciferase functional highlight identify inactive inhibitor inhibitors of SARS-CoV-2 IPPA-17-A04 NADPH oxidase Nasal Epithelial cells pandemic Prevent Pro protease quantification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Setanaxib structures therapeutic Therapeutic strategies Vidofludimus viral replication virus was used [DOI] 10.3390/v13091814 PMC 바로가기 [Article Type] Article
The New Generation h DHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human CoronavirusesArticle Published on 2021-08-142022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] hDHODH inhibitor addition Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral agent biosynthesis pathway broad-spectrum antiviral cells cellular combination treatment contribute coronavirus coronavirus CoV COVID-19 CoVs de novo develop development DHODH drug effective embryonic enzyme Generation Human in vitro infections inhibited inhibitor kidney organoid lack New organoids Other pandemic Pandemics predicted prevented Probability pyrimidine biosynthesis Replication reversed SARS-CoV-2 stem cells therapeutic intervention Threats uridine zoonotic disease [DOI] 10.3390/microorganisms9081731 PMC 바로가기 [Article Type] Article
DHODH and cancer: promising prospects to be exploredReview Published on 2021-05-102022-10-31 Journal: Cancer & Metabolism [Category] COVID-19, [키워드] association Cancer Cancer cells Cancer metabolism Cancer therapy de novo De novo pyrimidine biosynthesis DHODH DHODH inhibitors dihydroorotate dehydrogenase disease Effect enzyme Evidence Human inhibitor mechanism Mitochondria mitochondrial multiple sclerosis pathway rheumatoid arthritis therapeutic target Therapies Treatment Tumor tumor progression [DOI] 10.1186/s40170-021-00250-z PMC 바로가기 [Article Type] Review
Leflunomide an immunomodulator with antineoplastic and antiviral potentials but drug-induced liver injury: A comprehensive review항종양 및 항바이러스 잠재력을 갖지만 약물 유발 간 손상을 갖는 레플루노마이드 면역조절제: 포괄적인 검토Review Published on 2021-04-012022-09-11 Journal: International immunopharmacology [Category] SARS, 임상, 치료제, [키워드] affected Anti-inflammatory Antineoplastic Antiviral antiviral activity approved Arthritis Autoimmune benefit Bilirubin Biomarkers catalytic Cell cell growth cellular Combination Compound COVID-19 Cytokines de novo synthesis DHODH drug drug-induced Drug-induced liver injury enzyme event growth hepatic impairment hepatic injury Immunoglobulin immunological immunomodulator Immunosuppression inhibit inhibitors joint destruction leflunomide Leflunomide. liver liver enzyme liver enzymes Liver injury membrane mitochondrial nucleotide nucleotides off-label outcome Pathogenesis pathophysiology Patient Perspective pharmacological precautions proliferation Protective Protein pyrimidine reducing Regulatory Relapsing-Remitting Multiple Sclerosis reported required responsible Rheumatoid safety profile SARS CoV SARS CoV-2 serum Treatment Trial tyrosine with COVID-19 [DOI] 10.1016/j.intimp.2021.107398 PMC 바로가기 [Article Type] Review
The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokinesArticle Published on 2021-01-152023-07-12 Journal: Virus research [Category] SARS, [키워드] Antiviral coronavirus COVID-19 cytokine Cytokine storm DHODH PTC299 SARS-CoV-2. [DOI] 10.1016/j.virusres.2020.198246 PMC 바로가기
IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In VitroArticle Published on 2020-12-052022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Analysis anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity anti-SARS-CoV-2 therapeutics Antiviral antiviral activity antiviral efficacy antiviral potency antiviral therapy Autoimmune diseases candidate Combination Concentration coronavirus cytotoxic effect demonstrated developmental DHODH dihydroorotate dehydrogenase (DHODH) inhibitors drug ELISA half-maximal effective concentration host-directed antivirals (HDAs) immunofluorescence IMU-838 in vitro in vivo Infection inhibitor investigated Lineage pandemic pathogenic viruses Patient phase Protein reduction Remdesivir RNA synthesis RT-qPCR SARS-CoV-2 show Spread Trial Vero Vero Cell Vidofludimus viral replication [DOI] 10.3390/v12121394 PMC 바로가기 [Article Type] Article
Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2Research Article Published on 2020-08-042022-10-29 Journal: Protein & Cell [Category] COVID-19, MERS, SARS, [키워드] de novo pyrimidine biosynthesis Antiviral Antiviral effect antiviral efficacy broad-spectrum antiviral cells circulating coronavirus SARS-CoV-2 DHODH DHODH inhibitors drug drug-likeness Ebola virus Epidemics Host immuno-regulation in vivo infected cells influenza A virus influenza viruses inhibitor knock-out mutated novel novel coronavirus SARS-CoV-2 outbreak Pandemics pharmacokinetic profiles reported RNA virus RNA viruses SARS-CoV-2 supplementary material virus virus replication Zika virus [DOI] 10.1007/s13238-020-00768-w PMC 바로가기 [Article Type] Research Article